Born July 19, 1988, in Longview, Texas, Trent Williams attended Longview High School, where he starred for the Lobos alongside future NFL players Malcolm Kelly, Chris Ivory, and Robert Henson. A unanimous first-team all-district selection as a senior, Williams also competed in track and field as a shot putter. Initially a three-star recruit ranked as the nation's twenty-eighth offensive guard prospect, he chose the University of Oklahoma over Louisiana State, Oklahoma State, and Texas A&M.
Williams played for coach Bob Stoops's Oklahoma Sooners from 2006 to 2009, becoming the starter at right tackle as a true freshman after Branndon Braxton suffered a broken leg. As a junior in 2008, he anc...